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DILATREND® / CO-DILATREND®
Active ingredient:Carvedilol Carvedilol / Hydrochlorothiazide
DILATREND® contains the active substance carvedilol, which is a third generation, multiple action adrenergic receptor blocker with ß1-, ß1- and ß2-adrenergic receptor blockade properties and additional anti-inflammatory and anti-oxidative characteristics.
CO-DILATREND® further contains hydrochlorothiazide, that acts as diuretic by inhibition of the renal reabsorption of sodium and chloride.
The active substance carvedilol is listed in the WHO list of essential medicines in the sections of antihypertensive medicines, medicines used in heart failure, antianginal medicines and antiarrhythmic medicines as well. According to many major clinical practice guidelines (e.g. United States, Europe, Australia), ß-blockers like carvedilol are first line therapy for the management of stable angina pectoris, additionally indicated as adjunctive therapy for the treatment of congestive heart failure and essential hypertension.