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ALDACTONE® contains as active substance spironolactone, which belongs to the pharmaceutical class of potassium-sparing diuretics. ALDACTONE® acts predominantly as a competitive antagonist of aldosterone leading to reduction of sodium reabsorption and potassium excretion by blocking the sodium-potassium exchange in the late distal tubules and collecting ducts of the kidney. The active substance spironolactone is listed in the WHO list of essential medicines in the sections of medicines used in heart failure and diuretics as well. With regard to the mode of action, ALDACTONE® is indicated in the treatment of primary and secondary hyperaldosteronism as well as edema due to hepatic cirrhosis, heart insufficiency or nephrotic syndrome, and respiratory insufficiency with chronic cor pulmonale. Furthermore, spironolactone is effective as add-on therapy in hypertension.